Dengue Modulates Mature-GILT Production to Increase Host Cell Susceptibility to Infection
Hector A. Trujillo, Williams College
2014 University of California Summer Research Training Program
Nevan Krogan, Ph.D., Jeffrey Johnson, Ph.D.
Department of Cellular and Molecular Pharmacology, University of California San Francisco
The research I did this summer was dissecting molecular mechanisms Dengue virus uses to increase its infectivity towards host cells. Specifically, my lab realized that an immune protein (called GILT) was significant down-regulated upon Dengue infection, and the literature showed that GILT was integral for resistance against dengue infection. So my lab wanted to characterize the GILT interactome. That is, what does GILT interact with normally? How do these interactions change upon viral infection? Hector’s poster was chosen for an award to attend the American Society for Microbiology in New Orleans, spring 2015.